[PDF] Non-nutritive Sweeteners and Their Associations with Obesity and Type 2 Diabetes | Semantic Scholar (2024)

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@article{Walbolt2020NonnutritiveSA, title={Non-nutritive Sweeteners and Their Associations with Obesity and Type 2 Diabetes}, author={Jarrett Walbolt and Yunsuk Koh}, journal={Journal of Obesity \& Metabolic Syndrome}, year={2020}, volume={29}, pages={114 - 123}, url={https://api.semanticscholar.org/CorpusID:219170495}}
  • Jarrett Walbolt, Y. Koh
  • Published in Journal of Obesity… 2 June 2020
  • Medicine

It is imperative to understand the NNS efficacy and the relationship between NNS and metabolic diseases, as it is suggested that NNS may actually contribute to the development or worsening of metabolic diseases.

21 Citations

Background Citations


Methods Citations


Figures and Tables from this paper

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21 Citations

The effect of sweeteners on carbohydrate metabolism, metabolic parameters and intestinal microbiota
    N. V. SilinaN. V. MazurinaE. V. ErshovaK. Komshilova

    Environmental Science, Medicine

    Obesity and metabolism

  • 2024

A review of studies that have shown different effects of non-calorie sweeteners on carbohydrate and fat metabolism, body weight, the composition of intestinal microbiota, as well as the regulation of eating behavior shows that low-calorie sugar substitutes can be used in obese people as part of a comprehensive weight loss program.

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Letter: Non-Nutritive Sweeteners May Have a Bell-Shaped Dose Response for Dysbiosis-Related Adverse Effects That Contributed to Discrepancies between Prospective Cohort and Randomized Controlled Studies
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  • 2020

Increased weight gain with reduced food intake in livestock fed NNS suggested the existence of a true adverse effect of NNS on obesity and its closelyassociated diabetes.

Nutritive/non-nutritive sweeteners and high fat diet contribute to dysregulation of sweet taste receptors and metabolic derangements in oral, intestinal and central nervous tissues
    Yiyuan ZhangLu Chen Hong Ding

    Medicine, Environmental Science

    European Journal of Nutrition

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Investigation of the effects of long-term consumption of nutritive or non-nutritive sweeteners with or without high fat diet on sweet taste receptor expression in nutrient-sensing tissues and energy regulation dependent on sweet-Sensing found down-regulation in the tongue and hypothalamus and alterations in hypothalamic appetite signals.

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Non-nutritive sweeteners and their impacts on the gut microbiome and host physiology
    Irene L. RichardsonS. Frese

    Medicine, Environmental Science

    Frontiers in Nutrition

  • 2022

The history and current knowledge of non-nutritive sweeteners, their reported utility and effects on host physiology and the gut microbiome are discussed, and a model for investigating the underlying mechanism behind reported effects of NNS on the Gut microbiome is described.

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Impact of Dietary Sugars on Gut Microbiota and Metabolic Health
    Karina GarciaGonçalo FerreiraF. ReisS. Viana

    Medicine, Environmental Science


  • 2022

Future research should consider gender and species vulnerability when the impact of such substances on GM community and metabolic health is scrutinized in order to guide their adequate use at doses relevant to human use.

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Aspartame and Its Metabolites Cause Oxidative Stress and Mitochondrial and Lipid Alterations in SH-SY5Y Cells
    L. V. GriebschE. L. Theiss H. Grimm

    Medicine, Environmental Science


  • 2023

Treatment of the human neuroblastoma cell line SH-SY5Y with aspartame or its three metabolites resulted in significantly elevated oxidative stress associated with mitochondrial damage, which was illustrated with reduced cardiolipin levels, increased gene expression of SOD1/2, PINK 1, and FIS1, and an increase in APF fluorescence.

Consumption of Ultra-Processed Foods Is Associated with Free Sugars Intake in the Canadian Population
    Virginie HamelMilena NardocciN. FlexnerJodi T BernsteinM. L’AbbéJean-Claude Moubarac

    Medicine, Environmental Science


  • 2022

Investigating the association between UPF consumption and free sugars intake in the Canadian population found that almost half of the population’s energy intake came from UPF, and most of these calories came from free sugars.

Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoE−/− Mice
    Cheng‐Hsin LinHung-Yuan LiShu-Huei WangYue‐Hwa ChenYangqin ChenHung-Tsung Wu

    Medicine, Environmental Science


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A concurrent consumption of AceK exacerbated HCD-induced dyslipidemia and atherosclerotic lesion in ApoE−/− mice, and AceK might increase the risk of atherosclerosis under HCD.

Approaches to Enhance Sugar Content in Foods: Is the Date Palm Fruit a Natural Alternative to Sweeteners?
    E. Sayas-BarberáConcepción Paredes José A. Pérez-Álvarez

    Environmental Science, Agricultural and Food Sciences


  • 2023

The current levels of added sugars in processed foods impact dental health and contribute to a range of chronic non-communicable diseases, such as overweight, obesity, metabolic syndrome, type 2

Is a Non-Caloric Sweeteners-Free Diet Good To Treat Functional Gastrointestinal Disorder Symptoms? A Randomized Controlled Trial
    V. M. Mendoza-MartínezM. Zavala-Solares Nallely Bueno-Hernández


  • 2021

This study shows that diet c-NCS associates with increased FGDs including diarrhea, post-prandial discomfort, constipation, and burning or retrosternal pain, and a NCS-f diet could be a complementary strategy to alleviate FGDs.

  • PDF



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Serum metabolomics analysis revealed aspartame to be rapidly metabolized and to be associated with elevations in the short chain fatty acid propionate, a bacterial end product and highly gluconeogenic substrate, potentially explaining its negative affects on insulin tolerance.

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Evidence from RCTs does not clearly support the intended benefits of nonnutritive sweeteners for weight management, and observational data suggest that routine intake of non-nutritives may be associated with increased BMI and cardiometabolic risk.

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Nonnutritive Sweeteners in Breast Milk
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Nonnutritive sweeteners, including saccharin, sucralose, aspartame, and acesulfame-potassium, are commonly consumed in the general population, and all are considered safe for use during pregnancy and lactation.

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